TL Genomics Inc.

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Product & Technology

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■Preventing clogging formation inside the chip during blood cell separation

  TL Genomics has invented a breakthrough technology, which prevents clogging formation inside PDMS chip. This patented technology enables blood sample to pass for a several hours or more.

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■Mass Production technology of multi-layered PDMS chip

  Our microfluidics device has a unique feature of multi-layered structure, which enables a lot of sample liquid to run at significantly high flow rate. Thus 20ml or more blood sample, for example, can be treated.

  TL Genomics has invented a mass production technology of such multi-layered PDMS chip by an injection mold and assemble technology. Small scale butch is compatible and of course a large-scale muss production is now available.

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  Patents and know-hows are owned by TL Genomics.  We are happy to offer out-license or collaboratively develop a new application.

 

 ■Applications

  - fetal cells in maternal blood stream (now under studied in EU)

  - immune cells for ex vivo cell therapy

  - CTCs 

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  Digital multi scatering, named DimuScat, is a powerful method to detect copy number variations and point mutations at the same time in a single reaction of digital PCR.

 

  One of the applicaton of DimuScat is to detect chromosomal anueploidies and microdeletion (DimuScat 13/18/21/22/XY), which will be substituted for QF-PCR.

 

  In this system, major trisomies and microdeletion (22q11) as well as sex chromosomes are detected in a single panel. Moreover, 21 trisomies are detected by different sets of probes that are located in separate locus, so that the translocation type and the isochromosomal trisomy can be distinguished.

 

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   Patents are filed by TL Genomics.  DimuScat is now ready for out-license or clinically developed in collaboration.

 

2020.10.25 Sunday